Targeted suppression of SPP1 inhibits tumor invasion and metastasis in NRF2 hyperactivated cisplatin resistant HNSCC - PubMed
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- #SPP1
- #NRF2
- #HNSCC
- SPP1 is overexpressed in NRF2-hyperactivated cisplatin-resistant HNSCC and drives aggressive tumor behavior.
- Targeting SPP1 improved cisplatin sensitivity, inhibited invasion and metastasis in HNSCC models.
- SPP1 suppression dysregulated oncogenic pathways like MAPK, AKT/mTOR, FAK, and PAK1.
- SPP1 interacts with integrins and CD44 receptors, linking to interferon and EMT signatures in tumors.
- High SPP1 expression correlates with poor prognosis and NFE2L2/KEAP1 mutations in HNSCC patients.