Clinical and biological markers of electroconvulsive therapy effectiveness: a narrative review - PubMed
3 months ago
- #Electroconvulsive Therapy
- #Psychiatric Disorders
- #Biomarkers
- ECT is highly effective for severe or pharmacotherapy-resistant psychiatric disorders.
- Clinical markers like higher age, psychotic symptoms, and absence of personality disorders predict better ECT response in depressive disorders.
- Biomarkers at genetic/epigenetic, immune inflammatory, and brain imaging levels show promise in predicting ECT response.
- Genetic studies indicate higher genetic risk in patients referred for ECT, but predictive value of polygenic risk scores remains inconsistent.
- Combining clinical features and biomarkers may help define subgroups of psychiatric disorders and predict treatment outcomes.
- Specific clinical symptoms and inflammatory markers (e.g., IL-6, CRP) may indicate differential response to ECT.