Proteomic Risk Score for Prediction of Incident Hypertension - PubMed
2 days ago
- #hypertension
- #proteomics
- #risk prediction
- A proteomic risk score (ProtRS) was developed to predict incident hypertension using UK Biobank Proteomics data.
- The ProtRS improved prediction models when added to demographics, clinical variables, and a polygenic risk score (PRS).
- External validation in the Asklepios study confirmed the ProtRS's predictive ability for hypertension risk.
- Pathway analysis linked the ProtRS to neutrophil degranulation, insulin-like growth factor, PI3K signaling, and extracellular matrix remodeling.
- The study suggests proteomic information can enhance individualized hypertension risk stratification and provide biological insights.