Targeting FGFR1-regulated SPP1 signaling repolarizes immunosuppressive macrophages and sensitizes Hepatocellular Carcinoma to anti-PD-1 therapy - PubMed
5 days ago
- #Immunotherapy
- #FGFR1
- #Hepatocellular Carcinoma
- Targeting FGFR1-regulated SPP1 signaling repolarizes immunosuppressive macrophages and sensitizes Hepatocellular Carcinoma (HCC) to anti-PD-1 therapy.
- ICB resistance in HCC is associated with FGFR1 upregulation, activating MAPK signaling and inducing SPP1 expression, promoting M2-type macrophage polarization and suppressing T cell function.
- SPP1 knockdown or neutralization reduces macrophage accumulation and restores T cell infiltration in tumors.
- Pharmacological inhibition of FGFR1 with BGJ398 synergizes with anti-PD-1 therapy, enhancing antitumor efficacy in preclinical models.
- High FGFR1 expression correlates with poor responses to ICB in HCC patients, suggesting FGFR1 as a predictive biomarker.