Mechanistic insights into nicardipine's anti-colitic action: inhibition of pro-inflammatory cytokines, attenuation of oxidative stress, and protection of the mucosal barrier - PubMed
5 hours ago
- #Oxidative Stress
- #Colitis
- #Nicardipine
- Nicardipine, primarily used for hypertension and angina, shows anti-inflammatory properties in a murine model of DSS-induced colitis.
- The study involved 50 mice divided into control, DSS-induced, and two nicardipine treatment groups (12 and 24 mg/kg).
- Nicardipine treatment reduced weight loss, DAI scores, and histological damage in DSS-induced colitis.
- It suppressed NF-κB mRNA expression and reduced levels of pro-inflammatory cytokines (IL-6, IL-1β, TNF-α) and COX-2.
- Nicardipine also decreased oxidative stress markers (MPO, 8-OHdG) and restored claudin-1 expression, enhancing SOD activity.
- The protective role of nicardipine in colitis is attributed to its regulation of inflammation and oxidative stress pathways.