Skeletal muscle metabolism in health and disease: Mechanisms, interventions, and clinical perspectives - PubMed
7 hours ago
- #health
- #metabolism
- #skeletal muscle
- Skeletal muscle regulates systemic energy homeostasis through glucose uptake, fatty acid oxidation, and amino acid metabolism.
- Metabolic flexibility in skeletal muscle supports physical performance and protects against metabolic diseases like obesity, type 2 diabetes, and sarcopenia.
- Key regulators of skeletal muscle metabolism include insulin, AMPK, mTOR, and PGC-1α.
- Disruptions in metabolic pathways can lead to mitochondrial dysfunction, lipid dysregulation, and muscle wasting.
- Therapeutic interventions include pharmacological, exercise-based, and nutritional strategies, with a focus on mitochondrial-targeted approaches and myokine-mediated communication.
- Multi-omics technologies and inter-tissue communication are advancing precision medicine in skeletal muscle metabolism.
- A systems-level approach is essential for developing targeted therapies to enhance metabolic health and extend healthspan.