Lipid metabolic reprogramming of CD8+ T cells in the tumor microenvironment - PubMed
5 hours ago
- #Ferroptosis
- #T Cell Metabolism
- #Tumor Microenvironment
- Lipid metabolic reprogramming in the tumor microenvironment contributes to CD8+ T cell dysfunction and limits cancer immunotherapy efficacy.
- Hypoxia, acidosis, obesity, and hyperlipidemia collectively impose a metabolic siege on CD8+ T cells.
- Dysregulated lipid pathways include CD36-mediated uptake of oxidized lipids, which promotes ferroptosis.
- Cholesterol homeostasis disruption impairs TCR signaling and triggers endoplasmic reticulum stress via the IRE1α-XBP1 axis, leading to immune checkpoint expression.
- Therapeutic strategies involve modulating lipid transporters and metabolic engineering of CAR-T cells to restore T cell function.