Association of a novel triglyceride-glucose and non-HDL-to-HDL cholesterol ratio (TyG-NHHR) index with cardiometabolic multimorbidity: a dual-cohort prospective study in Chinese and European adults -
5 hours ago
- #cardiometabolic multimorbidity
- #metabolic index
- #insulin resistance
- TyG-NHHR index, combining triglyceride-glucose (TyG) and non-HDL-to-HDL cholesterol ratio (NHHR), is linked to higher cardiometabolic multimorbidity (CMM) risk in Chinese and European adults.
- Each standard deviation increase in TyG-NHHR raised CMM risk by 13%, with the highest quartile showing a 56% higher risk compared to the lowest quartile.
- Linear dose-response relationship found, and persistent high TyG-NHHR trajectories or cumulative exposure strengthened associations with CMM.
- Mediation analysis suggests insulin resistance significantly explains the link between atherogenic dyslipidemia and CMM, but not vice versa.
- TyG-NHHR is a simple, routine metabolic indicator that could aid early CMM risk identification and prevention in diverse, middle-aged to older populations.