MRAP2 potentiates GPCR signaling by conserved mechanisms that are disrupted by obesity-associated genetic variants - PubMed
10 hours ago
- #obesity genetics
- #MRAP2
- #GPCR signaling
- MRAP2 regulates GPCR signaling through conserved mechanisms.
- MRAP2 interacts with GPCRs like MC4R, MC3R, and GHSR, which are crucial for appetite regulation.
- MRAP2 forms 1:1 complexes with GPCRs, disrupting their homodimerization.
- MRAP2 enhances GPCR signaling by interacting with shared transmembrane regions.
- MRAP2 delays GPCR internalization by impairing β-arrestin-2 recruitment.
- Deletion of MRAP2's cytoplasmic region reduces GPCR signaling by affecting constitutive activity.
- Obesity-associated MRAP2 variants alter the constitutive activity of GPCRs.
- The study highlights the importance of GHSR constitutive activity in metabolism.