CD177⁺ neutrophil-platelet aggregates contribute to thromboinflammation via NETs in necrotizing enterocolitis - PubMed
3 hours ago
- #neutrophil-platelet aggregates
- #thromboinflammation
- #necrotizing enterocolitis
- CD177+ neutrophil-platelet aggregates (NPAs) contribute to thromboinflammation via NETs in necrotizing enterocolitis (NEC).
- NEC is a severe gastrointestinal disease affecting premature infants with unclear pathogenic mechanisms.
- Thromboinflammation in NEC is characterized by immunothrombosis with CD177+ neutrophils, activated platelets, and fibrin deposition.
- Blocking CD177+ NPAs or inhibiting NET formation alleviates NEC severity in mouse models.
- Elevated CD177+ NPA levels correlate with NEC severity and increased thrombotic biomarkers.
- Prophylactic low-molecular-weight heparin (LMWH) disrupts NPA formation, reduces NET burden, and improves survival in NEC.
- CD177+ NPAs are central drivers of NEC pathogenesis, suggesting LMWH therapy and NPA monitoring as potential clinical strategies.