Spatial and single-cell characterization of human glioblastoma tumor microenvironment reveals malignant cellular communities - PubMed
4 hours ago
- #Tumor Microenvironment
- #Spatial Transcriptomics
- #Glioblastoma
- Integrated spatial and single-cell omics data from 100 glioblastoma patients identified four consistent malignant cellular communities.
- Two mesenchymal-like tumor cell subpopulations were distinguished: MES-Hyp in hypoxic regions with macrophages, and MES-Ast associated with vascular cells.
- Study predicted and verified cell subtypes and ligand-receptor interactions involved in intercellular communication within these communities.
- Patch sequencing revealed synaptic connections primarily between neurons and oligodendrocyte-progenitor-like tumor cells.
- Findings offer insights into GBM spatial organization and intercellular communication, suggesting potential therapeutic targets.