The Mitochondrial Blueprint of Skin Aging: From Damage Signals to Dermatologic Interventions - PubMed
5 hours ago
- #skin-aging
- #dermatology
- #mitochondria
- Mitochondria play a central role in skin health by regulating ATP production, redox signaling, mitophagy, and cell fate decisions.
- Aging and UV exposure lead to mitochondrial defects, including DNA mutations, impaired oxidative phosphorylation, excessive ROS production, and disrupted fission-fusion dynamics.
- These defects contribute to energy metabolism decline, inflammation, fibroblast senescence, extracellular matrix degradation, pigmentary changes, and delayed wound healing.
- Mitochondrial stress propagates through the skin microenvironment via weakened antioxidant defenses and extracellular vesicles.
- Emerging mitochondria-targeted interventions include NAD+ precursors, antioxidants like melatonin and CoQ10, sirtuin activators, photobiomodulation, and NRF2-based redox reprogramming.
- Preclinical and clinical studies show these approaches can restore bioenergetics, reduce oxidative stress, and improve skin structure and function.
- Mitochondria are a promising therapeutic target for anti-aging and wound-care strategies in dermatology.