Targeting EHMT2 overcomes 5-fluorouracil resistance in colorectal cancer by modulating cell cycle and apoptosis - PubMed
a day ago
- #chemoresistance
- #epigenetics
- #combination therapy
- EHMT2 is significantly upregulated in colorectal cancer (CRC) patients with poor responses to the chemotherapy drug 5-fluorouracil (5-FU), correlating with lower overall survival.
- Knockdown of EHMT2 restores 5-FU sensitivity in resistant CRC cell lines by upregulating PPM1B, leading to G1 cell cycle arrest and apoptosis.
- Combination treatment with 5-FU and the EHMT2 inhibitor BIX-01294 synergistically suppresses tumor growth in mouse xenograft and patient-derived organoid models.