Large-scale metaproteomics of human gut microbiota reveals microbial functions in metabolic diseases and aging - PubMed
4 hours ago
- #metabolic diseases
- #metaproteomics
- #gut microbiome
- Large-scale metaproteomic study of 1,967 fecal samples from 1,399 middle-aged and elderly Chinese individuals.
- Identified microbial functions linked to 44 phenotypes, including aging and metabolic diseases.
- Aging-associated shifts in carbon metabolism and energy production driven by Bacillota, Bacteroidota, Actinomycetota, and Pseudomonadota species.
- Consistent depletion of Bacillota species and their proteins in metabolic diseases, affecting carbohydrate, energy, amino acid metabolism, and short-chain fatty acid production.
- Medication-associated features identified across diabetes, hypertension, and dyslipidemia.
- Megasphaera elsdenii identified as a hub species in type 2 diabetes, promoted by antidiabetic drugs and potentially regulating glucose homeostasis through butyrate production.
- Provides protein-level evidence of microbial functions in health and disease, highlighting potential therapeutic targets.