Colonic Engyodontium fungus triggers neutrophil antimicrobial activity to suppress Lactobacillus johnsonii-derived glutamic acid-maintained Tregs - PubMed
6 hours ago
- #microbiome
- #immunology
- #gastroenterology
- Commensal fungus Engyodontium sp. was isolated from mouse feces using a Dectin-2 Fc fusion protein.
- Engyodontium enhances neutrophil antimicrobial activity via the CARD9 pathway, exacerbating colitis.
- Lactobacillus johnsonii produces L-glutamic acid via the glsA gene, promoting Treg expansion through IL-2 receptor signaling.
- Patients with Crohn's disease and ulcerative colitis show increased Engyodontium and decreased L. johnsonii levels.
- Engyodontium induces calprotectin in human colonic neutrophils, while L-glutamic acid promotes human Treg expansion.
- The Engyodontium-calprotectin axis opposes the Lactobacillus-glutamate-Treg cascade, worsening colitis.