Functional hyaluronic acid/gelatin hydrogel accelerates the closure and healing of diabetic wounds - PubMed
5 hours ago
- #regenerative medicine
- #hyaluronic acid hydrogel
- #diabetic wound healing
- Functional hyaluronic acid/gelatin hydrogel accelerates diabetic wound healing.
- Hydrogel combines HA-CHO and Gel-ADH, crosslinked via Schiff base reaction, with PNIPAm for temperature-sensitive contraction.
- Loaded with Ten-2 (pro-angiogenic) and IB-367 (antimicrobial) peptides to enhance healing.
- Effective in suppressing bacterial growth and upregulating TGF-β1, α-SMA, and p-Smad2 for wound repair.
- Injectable hydrogel mimics myofibroblast contraction, adapting to skin dynamics for diabetic wound treatment.