Hippo signalling in cellular and tissue-level metabolism across health and disease - PubMed
5 hours ago
- #metabolism regulation
- #Hippo signalling
- #disease mechanisms
- Hippo signalling, known for controlling organ size and growth, also acts as a key regulator of metabolic adaptation.
- Nutrients, hormones, and energy stress influence Hippo-YAP/TAZ activity, which in turn affects glucose, lipid, amino acid, and nucleotide metabolism.
- The review highlights metabolite-specific checkpoints and tissue-specific Hippo functions in metabolic organs.
- Hippo signalling plays context-dependent roles in diseases like obesity, type 2 diabetes, liver diseases, cardiometabolic disease, and cancer.
- The bidirectional Hippo-metabolism axis offers new therapeutic opportunities, requiring cell-type- and disease-stage-specific targeting.