Epidemiology, risk factor and prognostic factor of young differentiated thyroid carcinoma with distant metastasis: a retrospective cohort study - PubMed
5 hours ago
- #distant metastasis
- #thyroid carcinoma
- #SEER database
- Study focused on young (<55 years) differentiated thyroid carcinoma (DTC) patients with distant metastasis (DM).
- DM prevalence was 0.65%, predominantly affecting the lungs (35.8%).
- Risk factors for DM included male sex, follicular histology, and advanced T4 and N1 stages.
- 5-year and 10-year overall survival (OS) rates were 83.6% and 73.3%, respectively.
- 5-year and 10-year cancer-specific survival (CSS) rates were 85.0% and 79.9%, respectively.
- Prognostic factors for OS and CSS included age, metastasis sites (lung, bone, liver, brain), and treatment (surgery, chemotherapy).
- Prognostic nomograms showed strong performance (C-index =0.87 for OS; C-index =0.85 for CSS).
- First population-level analysis of young DTC patients with DM, using SEER database.