A guardian role of TagA in protecting Mycobacterium tuberculosis from nitrosative killing - PubMed
5 hours ago
- #DNA repair
- #Mycobacterium tuberculosis
- #nitrosative stress
- TagA is crucial for Mycobacterium tuberculosis (Mtb) survival in M1-polarized macrophages and in early infection stages in mice.
- TagA provides resistance to DNA alkylation damage, specifically excising 3-methyladenine (3-MA) via catalytic residue Glu48, protecting against nitrosative stress in M1 macrophages.
- Inhibiting iNOS pharmacologically or genetically rescues survival defects in ΔtagA mutants, highlighting TagA's role in repairing nitrosative DNA damage.