Impact of corticosteroid administration on glioblastoma progression before and after adjuvant treatments: recent updates on contradictory findings and mechanistic interactions - PubMed
5 hours ago
- #temozolomide resistance
- #glioblastoma
- #corticosteroids
- Corticosteroids, especially dexamethasone (DEX), are commonly used to manage glioblastoma and grade 4 astrocytoma due to their effectiveness in reducing cerebral edema and neurological symptoms.
- The impact of corticosteroids on tumor biology and treatment response is controversial, with some studies showing anti-proliferative effects while others suggest detrimental interactions with radiotherapy (RT) and temozolomide (TMZ).
- Proposed mechanisms for negative effects include induction of chemoresistance, suppression of immune responses, and modulation of DNA damage repair pathways.
- Steroid receptor coactivator-1 (SRC-1) has been identified as a key mediator linking corticosteroid signaling to immune regulation and tumor recurrence.
- Emerging therapeutic strategies, including drugs targeting epigenetic regulators and metabolic pathways, show promise in mitigating steroid-associated resistance to TMZ.
- The findings highlight the need for optimized dosing, timing, and integrated treatment strategies to improve patient outcomes.