Sfrp2 in Microglia Inhibited S100a8-Mediated Neuroinflammation and Protected Neural Damage Following Retinal Ischemia-Reperfusion - PubMed
3 days ago
- #retinal ischemia
- #neuroinflammation
- #microglia
- Sfrp2 is highly expressed in the retina following ischemia-reperfusion (I/R) injury.
- Sfrp2 localizes in microglia in the I/R model.
- Microglial Sfrp2 deficiency worsens retinal damage, neuronal degeneration, and inflammation in I/R.
- Sfrp2 deficiency activates the TRAF6-TAK1-NF-κB signaling pathway, increasing inflammatory mediator S100a8.
- S100a8 inhibitor partially mitigates retinal injury caused by Sfrp2 deficiency.
- Sfrp2 in microglia protects the retina by inhibiting neuroinflammation in I/R.