The Role of the Golgi Apparatus in Neurodegeneration - PubMed
11 hours ago
- #Golgi-apparatus
- #Neurodegeneration
- #Neurons
- The Golgi apparatus plays a key role in protein and lipid trafficking, processing, and modification.
- It also regulates autophagy, apoptosis, DNA repair, and cytoskeletal functions.
- Golgi fragmentation is an early pathological feature in neurodegenerative diseases like Alzheimer's, Parkinson's, and ALS.
- Neurons have unique Golgi structures called Golgi outposts and satellites, which are poorly understood.
- Dysfunction of the Golgi apparatus may contribute to neurodegeneration but is understudied compared to other mechanisms.