Adaptive deep brain stimulation in Parkinson's disease - PubMed
5 hours ago
- #Parkinson's disease
- #neuromodulation
- #deep brain stimulation
- Adaptive deep brain stimulation (aDBS) modulates stimulation amplitude in real-time based on subthalamic beta activity (13-30 Hz).
- aDBS shows potential benefits over conventional DBS in motor improvement, side-effect reduction, and energy efficiency.
- Technical developments include sensing-enabled devices, stimulation algorithms, and new clinical indications.
- Limitations include physiomarker variability, signal artifacts, and lack of standardized programming protocols.
- aDBS represents a shift towards physiomarker-guided neuromodulation, requiring new infrastructure, training, and real-world studies.
- The approach promises more personalized and responsive treatment for Parkinson's disease.