Developmental organization of sensory and sympathetic ganglia - PubMed
18 hours ago
- #neural crest
- #CRISPR barcoding
- #developmental biology
- Neural crest cells give rise to diverse cell types but their lineage relationships and fate specification timing are unclear.
- CRISPR barcoding in mice and mosaic variant analysis in humans show neural crest progenitors spread rostrocaudally but with limited overlap between sensory and sympathetic lineages.
- Computational modeling suggests most neural crest cells are fate-restricted before delaminating from the neural tube.
- Real-time imaging in quail embryos reveals FGF-dependent rostrocaudal dispersion of neural crest cells across axial levels.
- The study supports a model where neural crest fate bias arises primarily within the neural tube, with only a small subset of delaminated progenitors retaining multipotency for sensory and sympathetic derivatives.