Mitochondrial kinase CMPK2 in immune homeostasis and disease: from metabolic regulation to inflammatory signaling - PubMed
18 hours ago
- #immune regulation
- #mitochondrial kinase
- #therapeutic target
- CMPK2 is a mitochondrial enzyme vital for nucleotide metabolism, immune regulation, and disease processes.
- It maintains mitochondrial DNA integrity and energy metabolism, linking mitochondrial stress to inflammation via pathways like NLRP3 and cGAS-STING.
- Upregulated during viral infections such as SARS-CoV-2 and Zika, CMPK2 restricts virus replication and boosts antiviral defenses.
- CMPK2 dysregulation is implicated in diseases like systemic lupus erythematosus and neuroblastoma, highlighting its potential as a diagnostic biomarker and therapeutic target.
- This review establishes CMPK2 as a key node connecting mitochondrial metabolism, immune responses, and disease mechanisms, calling for further research into its functions and clinical applications.