BRCA2-dependent maturation of nascent strands during DNA replication - PubMed
6 hours ago
- #DNA replication
- #PARP inhibitor
- #BRCA2
- PARP inhibitor olaparib impedes nascent DNA strand maturation by targeting unligated Okazaki fragments.
- Wild-type human cells overcome olaparib-induced impediment via a BRCA1/BRCA2-dependent process that repairs thousands of single-strand breaks/gaps.
- This repair process involves RAD51 accumulation in chromatin and operates on large nascent strand fragments hundreds of kilobases behind replication forks.