Hasty Briefsbeta

Bilingual

Latent, Lytic, and Linked to Multiple Sclerosis-How EBV Drives Autoimmunity - PubMed

11 hours ago
  • #Autoimmunity
  • #Epstein-Barr virus
  • #Multiple Sclerosis
  • Epstein-Barr virus (EBV) is linked to multiple sclerosis (MS) and drives autoimmunity.
  • EBV oncogenes may induce B cell subsets that initiate neuroinflammation.
  • Insufficient immune control allows T-bet+CXCR3+ B cells to infiltrate the CNS, contributing to MS.
  • These B cells attract other lymphocytes, stimulate T cells, and produce autoantibodies.
  • Targeting CNS-infiltrating B cells with EBV-specific treatments could complement MS therapies.