The endothelium response to kidney injury - PubMed
5 hours ago
- #endothelium
- #vascular biology
- #kidney injury
- The kidney has a heterogeneous endothelial cell population, divided into vascular, glomerular, and lymphatic endothelia.
- Vascular endothelium supports parenchymal cells by delivering oxygen, nutrients, and removing waste.
- Glomerular endothelium maintains the glomerular filtration barrier, allowing selective passage of water and electrolytes.
- Lymphatic endothelium aids in reabsorbing extracellular fluid and immune cell trafficking to lymph nodes.
- After kidney injury, endothelial populations undergo changes like increased inflammatory cytokines and reduced angiogenic molecules.
- Endothelial dysfunction can lead to capillary rarefaction, impaired barrier function, and influence recovery or progressive damage.
- Therapeutic targeting of kidney endothelium post-injury may improve outcomes in kidney disease.