Molecular characterization of humanized APOE mouse models reveals source and genotype dependent differences - PubMed
5 hours ago
- #APOE
- #Mouse model
- #Alzheimer’s disease
- Molecular characterization of humanized APOE mouse models reveals source and genotype dependent differences.
- Keywords include APOE, Alzheimer’s disease, Lipids, Mass spectrometry, Mouse model, Proteomics, and Transcriptomics.
- All animal procedures were approved by the Mayo Clinic Institutional Animal Care and Use Committee (IACUC) and followed NIH guidelines.
- Authors have declared competing interests, including consulting roles and advisory board memberships in various pharmaceutical and biotech companies.
- References include studies on apolipoprotein E (APOE) gene, its influence on amyloid-beta clearance, and its role in Alzheimer's disease.