Effect of Cognitive Reserve on Age at Symptom Onset and Cognitive Decline in Individuals With Dominantly Inherited Alzheimer Disease - PubMed

6 hours ago

Cognitive reserve (CogR) in dominantly inherited Alzheimer disease (DIAD) was modeled using a residual-based approach, separating cognitive performance into demographic (CogD), biomarker (CogB), and reserve components.
In asymptomatic DIAD carriers, higher CogR was associated with increased odds of being clinically unimpaired (CDR-SB = 0), with a 1 SD increase leading to a 4.06-fold rise in odds.
Among symptomatic carriers, higher CogR and CogB were linked to reduced baseline Clinical Dementia Rating-Sum of Boxes (CDR-SB) scores, indicating slower cognitive decline.
The study suggests cognitive reserve delays symptom onset and slows progression in DIAD, highlighting its protective role in genetically determined Alzheimer disease.

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