Photoreceptor Vulnerability to Ferroptosis: Membrane Phospholipid Peroxidation, Mitochondrial Homeostasis, and RPE-Photoreceptor Coupling - PubMed
4 hours ago
- #photoreceptor
- #ferroptosis
- #lipid peroxidation
- Photoreceptor degeneration is a key feature in many blinding retinal diseases.
- Ferroptosis-associated lipid peroxidation is a mechanism of photoreceptor vulnerability.
- Factors include high DHA/PUFA content in outer-segment membranes, high metabolic demand with specialized mitochondria, and RPE-photoreceptor metabolic coupling.
- Antioxidant defenses involve the xCT-GSH-GPX4 axis and mitochondrial GPX4.
- Therapeutic strategies aim to reduce lipid peroxidation, stabilize mitochondria, and restore RPE-PR support.