Autophagy-centered regulation of PI3K/Akt/mTOR and MAPK signaling by traditional Chinese medicine in gastric cancer - PubMed
5 hours ago
- #Autophagy
- #Gastric Cancer
- #Traditional Chinese Medicine
- Gastric cancer (GC) is a major health burden with high incidence and mortality, especially in East Asia.
- Conventional treatments like surgery and chemotherapy face limitations due to resistance and toxicity.
- PI3K/Akt/mTOR and MAPK signaling pathways are central to GC pathogenesis, promoting proliferation and metastasis.
- Traditional Chinese Medicine (TCM) regulates these pathways, inducing autophagy and apoptosis.
- Single herbal monomers (e.g., curcumin, berberine) and classical herbs (e.g., Huangqin) modulate key signaling molecules.
- Compound TCM formulas target multiple pathways, reversing EMT and chemoresistance.
- TCM enhances efficacy when combined with Western therapies like chemotherapy and immunotherapy.
- Challenges include research variability and standardization issues.
- Future directions focus on high-quality trials, omics integration, and precision TCM.