KIF20A inhibits TRIM21-dependent ubiquitination of DHX9 to boost SOX2 stability, enhancing OSCC stemness and ferroptosis resistance - PubMed
3 months ago
- #OSCC
- #KIF20A
- #ferroptosis
- KIF20A is overexpressed in OSCC and linked to poor clinical outcomes.
- KIF20A interacts with DHX9, inhibiting its TRIM21-mediated ubiquitination and degradation.
- Stabilized DHX9 enhances SOX2 mRNA stability, promoting CSC maintenance and ferroptosis resistance.
- KIF20A activates the PI3K/AKT pathway, supporting stemness and ferroptosis resistance in OSCC.
- ENMD-2076 reduces KIF20A expression, attenuates CSC traits, and enhances cisplatin sensitivity.
- Targeting KIF20A may improve therapeutic outcomes in OSCC, either alone or with chemotherapy.