Identifying a fatty acid metabolic gene signature in diabetic cardiomyopathy through integrated bioinformatics and machine learning - PubMed
5 hours ago
- #Diabetic cardiomyopathy
- #Fatty acid metabolism
- #Multi-omics
- Diabetic cardiomyopathy (DCM) is a major cardiovascular complication of diabetes, leading to heart failure and increased mortality.
- Seven genes (Hmgcs2, Ech1, Acot2, Acot1, Fbp2, Fkbp5, Decr1) were identified as upregulated in DCM, primarily in cardiomyocytes.
- Experimental validation in DCM mice confirmed increased mRNA and protein levels of Hmgcs2, Ech1, Acot1, Fbp2, and Decr1.
- Metabolomics revealed decreased NAD and cyclic ADP-ribose, alongside increased free fatty acids, indicating enhanced fatty acid metabolism.
- Ech1 and Fbp2 are newly implicated in DCM progression, offering potential diagnostic and therapeutic targets.