Patient and public involvement and engagement in clinical trials at scale: Analysis of the first 3250 responses on the POrtal for Patient and Public Engagement in Dementia (POPPED) - PubMed
6 hours ago
- #dementia research
- #patient engagement
- #clinical trials
- Study explores large-scale Patient and Public Involvement and Engagement (PPIE) in dementia research using a web-based approach.
- An online portal gathered public views on dementia research and a UK-based adaptive platform trial testing repurposed Alzheimer's drugs.
- 3,250 participants from 27 countries (87.4% UK-based) ranked four drugs and completed discrete choice experiments on treatment trade-offs.
- 79.6% of participants expressed positive attitudes toward the trial, with Metformin being the most preferred drug.
- Probability of severe side effects was the most influential treatment attribute, followed by mild side effects and type of evidence.
- Subgroup analyses by sex, age, and dementia experience supported the main findings.
- Web-based PPIE is effective for large-scale dementia research and provides a reusable resource for other studies.