Peritumoural adipose tissue promotes ferroptosis resistance by 3-hydroxykynurenine-mediated suppression of ferritinophagy - PubMed
15 hours ago
- #immunotherapy
- #cancer therapy
- #ferroptosis
- Peritumoural adipose tissue (PAT) contributes to cancer therapy resistance by promoting ferroptosis resistance.
- PAT upregulates ferritin (FTH1/FTL) and sequesters intracellular iron, mediated by kynurenine (KYN).
- KYN is metabolized to 3-hydroxykynurenine, which binds to NCOA4, inhibiting ferritinophagy and preventing ferritin degradation.
- Inhibition of the KYN pathway combined with PD-1 blockade suppresses tumour progression in murine models.
- The study highlights the PAT-KYN-ferritinophagy axis as a target to enhance immunotherapy in PAT-associated tumours.