Pneumococcal membrane particles promote serotype-independent cellular and humoral immunity and protect against pneumococcal colonization - PubMed
3 hours ago
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- Pneumococcal membrane particles (MP) have strong adjuvant properties and contain conserved antigens like MalX and PrsA.
- MP induce serotype-independent cellular and humoral immunity, including effector and memory Th17 responses in mice and humans, via TLR2 sensing.
- Intranasal MP immunization expands tissue-resident macrophages in the lungs and protects against pneumococcal colonization in mice without needing an adjuvant.
- MP show potential as a novel vaccine strategy against Streptococcus pneumoniae, addressing limitations of current pneumococcal conjugate vaccines (PCVs).