SARS-CoV-2 infection and vaccination elicit distinct pharyngeal mucosal B cell responses in children - PubMed
4 hours ago
- #SARS-CoV-2
- #B cell responses
- #mucosal immunity
- The study compares B cell responses in children after SARS-CoV-2 infection or vaccination at mucosal sites like tonsils and adenoids, as well as in blood.
- Infection leads to higher levels of IgA+ memory B cells and CXCR3+CD21+ B cells compared to vaccination.
- CXCR3+CD21+ B cells show greater clonal expansion, localization in pharyngeal tissues, and potential to become plasma cells, supported by persistent immune activation.
- Both infection and vaccination establish tissue-specific B cell memory, but the differences may impact the immunity's quality, durability, and location.