Adipocytes as core drivers of skin aging and novel targets for regeneration - PubMed
5 hours ago
- #Regenerative dermatology
- #Skin aging
- #Adipocyte senescence
- Adipocytes play a critical role in skin aging, not just as passive structural fillers but as active drivers.
- Age-related functional decline in adipocytes includes SASP, metabolic reprogramming, and altered adipokine secretion, contributing to ECM deterioration and inflammation.
- Regional heterogeneity of dermal white adipose tissue (dWAT) influences the variability in skin aging patterns.
- An adipocyte-immune-fibroblast network integrates signals to amplify aging phenotypes in the skin.
- Current anti-aging interventions often fail to address adipocyte dysfunction, highlighting the need for targeted therapies like senolytics and senomorphics.
- Adipocyte-targeted strategies could restore skin homeostasis and delay aging, offering new therapeutic opportunities.