FADD is recruited to activated STING oligomers to initiate caspase-mediated NF-κB activation in Drosophila melanogaster - PubMed
5 hours ago
- #Drosophila melanogaster
- #STING Pathway
- #Innate Immunity
- FADD interacts with activated STING oligomers in Drosophila melanogaster to initiate caspase-mediated NF-κB activation.
- FADD recruits DREDD (Caspase-8 homolog) downstream of STING to activate the NF-κB-like transcription factor Relish.
- A structural model shows FADD binding two separate STING dimers in oligomerized STING, explaining activation-dependent recruitment.
- FADD also interacts with IMD in a structurally distinct manner, highlighting its differential use in STING and IMD pathways.
- The study illustrates how an ancestral FADD/Caspase-8 module is incorporated into different innate immune pathways, offering insights into evolution of host-pathogen interactions.