UBE3A-mediated mH2A1 Ubiquitination activates TERT transcription to promote senescence resistance in pancreatic cancer - PubMed
6 hours ago
- #Pancreatic Cancer
- #UBE3A
- #Cellular Senescence
- UBE3A is significantly upregulated in pancreatic cancer tissues and correlates with poor patient outcomes.
- UBE3A inhibits cellular senescence in pancreatic cancer cells, promoting tumor proliferation and metastasis.
- UBE3A interacts with mH2A1, leading to its ubiquitination and degradation, which upregulates TERT transcription.
- The UBE3A/mH2A1/TERT axis enhances anti-senescence capacity in pancreatic cancer cells, driving malignant progression.
- Inhibition of UBE3A combined with the senolytic agent ABT-263 induces apoptosis and inhibits tumor growth.
- UBE3A may serve as a novel therapeutic target for pancreatic cancer.