Perioperative neurocognitive disorders: the importance of global systemic interactions - PubMed

5 hours ago

Perioperative neurocognitive disorders (PNDs) are cognitive impairments after anesthesia and surgery, often in older adults, linked to worse outcomes and higher mortality.
Key triggers of PNDs remain unknown or pathophysiology is incomplete, with current approaches focusing on isolated contributors.
The review highlights extrasynaptic GABAA receptors' role in PNDs, including their structure, function, and potential involvement post-anesthesia and surgery.
Advancing understanding of systemic neurobehavioral interactions and integrating known exposures, risk factors, and age-related neural changes is crucial for developing mechanism-based treatments.

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