Aquaporin-4 (AQP4) antibody-positive neuromyelitis optica spectrum disorder (NMOSD) complicated with acute pancreatitis: A case report - PubMed
5 hours ago
- #Neuromyelitis optica spectrum disorder
- #Acute pancreatitis
- #Autoimmune disease
- A 32-year-old female with AQP4-IgG-positive NMOSD developed acute pancreatitis (AP) during disease relapse, a rare extra-neurological manifestation.
- Diagnosis included spinal MRI showing hyperintense lesions and serological rise in AQP4-IgG titers, alongside lab tests confirming AP.
- Treatment involved methylprednisolone and mycophenolate mofetil for NMOSD, and gabexate with esomeprazole for AP, leading to symptom relief.
- The case suggests AQP4-IgG-mediated immune damage may extend beyond the CNS, indicating a possible link between NMOSD and AP.
- Highlights the need for clinical vigilance for systemic complications in NMOSD, expanding the understanding of its pathophysiological mechanisms.