Cross-ancestry genetic architecture reveals shared biological pathways of major psychiatric disorders - PubMed
6 hours ago
- #genetics
- #psychiatric disorders
- #cross-ancestry
- Cross-ancestry GWAS identified 403 loci linked to shared psychiatric disorder liability, including 88 novel regions.
- VRK2 (rs7596038) emerged as a robust shared genetic signal across European and East Asian populations.
- Gene prioritization highlighted 90 high-confidence candidates enriched in neurodevelopmental pathways.
- Single-nucleus RNA sequencing implicated excitatory neurons and astrocytes, with NCAM1-FGFR1 and NEGR1-NEGR1 pathways playing key roles.
- Mendelian randomization linked shared genetic liability to structural brain changes in emotion and cognition regions.
- Polygenic risk scores improved prediction accuracy for bipolar disorder and schizophrenia, showing trans-ancestry validity.
- Study underscores the importance of diverse ancestry research in precision psychiatry.