Enteropathy produced in mice by intergenerational transmission of small intestinal microbiota from undernourished children - PubMed
4 hours ago
- #intergenerational health
- #enteropathy
- #microbiome
- Undernourished children and mothers have environmental enteric dysfunction (EED), linked to gut barrier issues.
- A bacterial consortium from undernourished children's duodenal aspirates caused inflammation and growth impairment in mice and their offspring.
- The study identifies Campylobacter concisus as a key bacterium inducing inflammation via nitric oxide synthase-dependent pathways.
- This model helps develop microbiota-targeted therapies for intergenerational undernutrition.