Stress, stress systems, and Alzheimer's disease - PubMed
4 hours ago
- #stress hormones
- #Alzheimer's disease
- #neurodegeneration
- Chronic stress, early-life adversity, and trauma are linked to increased Alzheimer's disease risk.
- Stress hormones drive Alzheimer's pathology, including amyloid beta and tau aggregation, neuroinflammation, and neurodegeneration.
- Brain structures regulating stress response are vulnerable to early degeneration in Alzheimer's, complicating biomarker interpretation.
- Degeneration of stress neuroendocrine systems can accelerate Alzheimer's disease progression.
- Research implications include intervention strategies and clinical trial design for stress-related Alzheimer's factors.