Prolonged Cytokine Release Syndrome Is Associated With Hypofibrinogenemia After CD19-Directed CAR T-Cell Therapy in Adult Patients With Relapsed/Refractory Lymphoma - PubMed
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- #hypofibrinogenemia
- #CAR T-cell therapy
- #cytokine release syndrome
- Hypofibrinogenemia occurred in 25% of adult patients within 30 days after CD19-directed CAR T-cell therapy for relapsed/refractory lymphoma.
- Prolonged CRS (grade 1b), lower baseline fibrinogen levels, and use of axicabtagene ciloleucel were independent risk factors for developing hypofibrinogenemia.
- The study found no fatal bleeding events, and hypofibrinogenemia did not negatively impact overall survival or progression-free survival.