Maternal trans-vaccenic acid shapes neonatal T cell development and early-life immune imprinting - PubMed
4 hours ago
- #neonatal immunity
- #trans-vaccenic acid
- #maternal nutrition
- Maternal supplementation with trans-vaccenic acid (TVA), a trans-fatty acid in breast milk, promotes neonatal T cell development in mice.
- Neonates fed by TVA-enriched diet mothers showed expanded naïve CD4+ T cells and enhanced adaptive immunity against infection.
- TVA reprograms neonatal naïve CD4+ T cells via a G protein-coupled receptor-CCCTC-binding factor axis and promotes Th1-skewing with TBX21.
- Early-life exposure to maternal TVA through breastfeeding supports long-lasting antiviral immunity into adulthood.
- Findings highlight the benefits of maternal nutrition and breastfeeding in infant immune homeostasis and protective immunity.