Advances and Therapeutic Potential of Anthraquinone Compounds in Neurodegenerative Diseases: A Comprehensive Review - PubMed
5 hours ago
- #anthraquinones
- #neuroprotection
- #neurodegenerative-diseases
- Rhubarb's anthraquinones (e.g., emodin, aloe-emodin) show neuroprotective effects in neurodegenerative diseases (NDDs) like Alzheimer's and Parkinson's.
- Anthraquinones combat NDDs via antioxidant, anti-inflammatory actions, mitochondrial protection, and microglial regulation.
- They inhibit pyroptosis, apoptosis, tau phosphorylation, Aβ/α-synuclein aggregation, and modulate gut microbiota and blood-brain barrier permeability.
- Key pathways involved: Nrf2, ERK1/2, PI3K/mTOR, NLRP3, TLR4-NFκB, and Ca2+/EGFR/PLCγ.
- Clinical trials and brain-targeted delivery systems are needed to validate therapeutic potential.