Immune Patterns Shape Liver Hepatocellular Carcinoma Prognosis - PubMed
6 hours ago
- #Liver Cancer
- #Tumor Microenvironment
- #Immunotherapy
- Immune cell infiltration (ICI) and tumor genetic variability significantly influence liver hepatocellular carcinoma (LIHC) outcomes.
- The study utilized TCGA and GEO datasets, applying CIBERSORT and ESTIMATE algorithms to assess the tumor immune microenvironment (TIME) and tumor mutational burden (TMB).
- ICI scoring identified survival-associated clusters, with Cluster B showing improved survival.
- Gene subtype A was associated with prolonged survival and increased M1 macrophage infiltration.
- CST7 was identified as a key regulator, enhancing CD8+ T cell infiltration and synergizing with PD-1 antibody therapy.
- TMB correlated positively with ICI patterns and served as an independent prognostic marker for LIHC.
- CST7's role in improving ICI and PD-1 immunotherapy efficacy suggests its potential as a therapeutic target for LIHC.